June 10, 2015
Dr. Jag Sankar, University Distinguished Professor and Director of the NSF ERC-RMB, was recently recognized by the Governor of North Carolina with the Order of the Long Leaf Pine. The award is among the most prestigious civilian awards presented by the Governor to individuals who have a proven record of extraordinary service to the state. Notable recipients of this award in the past include Maya Angelou, Oprah Winfrey, Michael Jordan, William Friday, Charles Kuralt and Andy Griffith.
July 13, 2015
NSF Engineering Research Center for Revolutionizing Metallic Biomaterials is developing biodegradable metals for surgical implants
We all know that injuries happen and doctors sometimes have to use metal screws or plates to support broken bones while the bones heal. What if that implanted metal just disintegrated on its own after the injury heals?
A team at the NSF Engineering Research Center for Revolutionizing Metallic Biomaterials at North Carolina Agricultural and Technical State University is working to transform current medical and surgical treatments by creating "smart" implants. The major goal is to revolutionize metallic biomaterials to improve treatments for orthopedic, craniofacial, neural and cardiovascular ailments.
The National Science Foundation's (NSF) Engineering Research Centers are interdisciplinary, multi-institutional centers that join academia, industry and government in partnership to produce transformational engineered systems, along with engineering graduates who are highly skilled at innovation and primed for leadership in the global economy.
The research in this episode was supported by NSF award #0812348, NSF Engineering Research Center for Revolutionizing Metallic Biomaterials.
Link to Science Nation video: http://news.science360.gov/archives/20150713
11 AM – 11:50 PM – Friday, February 12, 2016
McNair Hall Lecture Room 4 – College of Engineering
Magnesium (Mg) and its alloys are promising candidates for use as bioresorbable materials for biomedical devices. Bioresorbables can degrade in situ following healing of the medical condition being treated, thus eliminating the need for second surgery to remove the device. A major impediment in the clinical use of Mg devices is the initial burst of corrosion activity, which generates gas pockets around the device. We evaluated the potential of alkylsilane self-assembled multilayer coatings to regulate Mg corrosion and to modify physicochemical properties and bioactivity of the coatings using surface functionalization. The coating was formed by co-polymerization of n-decyltriethoxysilane and tetramethoxysilane, followed by dip coating of metal disks. This resulted in the formation of a homogeneous microns-thick and defect-free coating. The coated surface was much more hydrophobic than bare Mg; however, functionalization of the coating with 3-aminopropyltriethoxysilane (APES) reduces the hydrophobicity of the coating. The coatings have resulted in a several-fold reduction in the corrosion rate as measured by hydrogen evolution and other assessment methods, and thus effectively prevented the initial corrosion burst. Our in vitro tissue culture studies demonstrated that MC3T3 cells can survive and proliferate on the coated Mg samples for two weeks and that the cell density was significantly higher on the APES-functionalized coatings. These results reveal excellent anticorrosive properties and cytocompatibility of the alkylsilane coatings and suggest a great potential for the use of these coatings on bioresorbable Mg devices.
Speaker: Avinash J. Patil, M. Tech, PhD candidate at the Bioengineering Department of the University of Pittsburgh.
Live stream: https://livestream.com/accounts/10428507/events/4805589