North Carolina A&T State University
NSF Engineering Research Center + Bioengineering Joint Seminar Series

Mussel-Inspired Electrospun Smart Magnetic Nanofibers
for Thermo-Chemotherapy

Chan-Hee Park, PhD

11:00 AM – 11:50 AM – Friday, January 29, 2016
Location: McNair Hall Lecture Room 4

A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effects of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.

About the speaker:

Dr. Chan-Hee Park received the B.Sc. Mechanical Engineering from ChonBuk National University and M.Sc. Biomedical Engineering from ChonBuk National University, Jeonju, South Korea, in 2001 and 2003 respectively. After graduating, he was a R&D engineer at National Instrument Korea Seoul, South Korea, from 2002 to 2009. He earned his PhD in Bionanosystem Engineering from ChonBuk National University. He is currently an Assistant Professor with the Department of Nano-Bio Mechanical System Engineering at ChonBuk National University, Jeonju, South Korea. He has published over 61 journal and conference articles, one book and he holds 22 Korea patents. His areas of interest are Nano-Bio Mechanical system engineering, Nano science, Biosensor, BioMEMS.