North Carolina A&T State University
NSF Engineering Research Center + Bioengineering Joint Seminar Series

Self-Assembling Organosilane Coating for Resorbable Magnesium Biomedical Devices

Avinash J. Patil
11:00 AM – 11:50 AM – Friday, February 12, 2016
Location: McNair Hall Lecture Room 4

Magnesium (Mg) and its alloys are promising candidates for use as bioresorbable materials for biomedical devices. Bioresorbables can degrade in situ following healing of the medical condition being treated, thus eliminating the need for second surgery to remove the device. A major impediment in the clinical use of Mg devices is the initial burst of corrosion activity, which generates gas pockets around the device. We evaluated the potential of alkylsilane self-assembled multilayer coatings to regulate Mg corrosion and to modify physicochemical properties and bioactivity of the coatings using surface functionalization. The coating was formed by co-polymerization of n-decyltriethoxysilane and tetramethoxysilane, followed by dip coating of metal disks. This resulted in the formation of a homogeneous microns-thick and defect-free coating. The coated surface was much more hydrophobic than bare Mg; however, functionalization of the coating with 3-aminopropyltriethoxysilane (APES) reduces the hydrophobicity of the coating. The coatings have resulted in a several-fold reduction in the corrosion rate as measured by hydrogen evolution and other assessment methods, and thus effectively prevented the initial corrosion burst. Our in vitro tissue culture studies demonstrated that MC3T3 cells can survive and proliferate on the coated Mg samples for two weeks and that the cell density was significantly higher on the APES-functionalized coatings. These results reveal excellent anticorrosive properties and cytocompatibility of the alkylsilane coatings and suggest a great potential for the use of these coatings on bioresorbable Mg devices.

About the speaker:
Avinash J. Patil, M. Tech, is currently a PhD student in the Bioengineering Department of the University of Pittsburgh. His research is sponsored by the ERC-RMB. Mr. Patil earned his B.E. degree (2002) in Chemical Engineering from Shivaji University and M.Tech. degree  (2007) in Bioengineering from the Indian Institute of Technology Bombay.  He worked at the Indian National Chemical Laboratory for two years under the mentorship of Dr. Ashish Lele. His work involved scaffold preparation from fibroin, a major silk protein. During his brief stay at National University of Singapore as an exchange student, he worked on electrospinning technology with Professor S. Ramakrishna. He has served as a judge in the Intel International Science and Engineering Fair, the world’s largest international pre-college science competition.

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