Publication details

Authors: Chen, Y. J.; Xu, Z. G.; Smith, C.; Sankar, J. 
Title: Recent advances on the development of magnesium alloys for biodegradable implants 
Type: Journal Article 
Publisher: Acta Biomaterialia 
Year: 2014 
Volume: 10 
Issue: 11 
Start Page: 4561 
End Page: 4573 
DOI: 10.1016/j.actbio.2014.07.005 
WEB-link: http://ac.els-cdn.com/S1742706114002992/1-s2.0-S1742706114002992-main.pdf?_tid=19138262-12ad-11e7-9b63-00000aacb360&acdnat=1490592212_68f4c7b87ae67b644375885587491ceb 
Abstract: In recent years, much progress has been made on the development of biodegradable magnesium alloys as "smart" implants in cardiovascular and orthopedic applications. Mg-based alloys as biodegradable implants have outstanding advantages over Fe-based and Zn-based ones. However, the extensive applications of Mg-based alloys are still inhibited mainly by their high degradation rates and consequent loss in mechanical integrity. Consequently, extensive studies have been conducted to develop Mg-based alloys with superior mechanical and corrosion performance. This review focuses on the following topics: (i) the design criteria of biodegradable materials; (ii) alloy development strategy; (iii) in vitro performances of currently developed Mg-based alloys; and (iv) in vivo performances of currently developed Mg-based implants, especially Mg-based alloys under clinical trials. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved. 
Keywords: magnesium alloys, design strategy, mechanical properties, corrosion, biodegradable implants, zn-zr alloy, in-vitro corrosion, stacking ordered structure, simulated body-fluid, rare-earth-elements, mg-si alloys, mechanical-properties, bio-corrosion, biomedical applications, grain-refinement