Publication details

Authors: Kuhlmann, J.; Dzugan, L. C.; Heineman, W. R. 
Title: Comparison of the Effects of Biofouling on Voltammetric and Potentiometric Measurements 
Type: Journal Article 
Publisher: Electroanalysis 
Year: 2012 
Volume: 24 
Start Page: 1732 
End Page: 1738 
DOI: 10.1002/elan.201200194 
Abstract: Biofouling of sensors is a common problem when measuring biological samples. The adherence of proteins and biomolecules, called hemostasis, is the first of four steps that lead to biofouling and eventually a foreign body response. This typically occurs within the first hours after the exposure of the biosensor to a biological sample. The purpose of this study was to assess the effect of this initial step of biofouling on cyclic voltammetry and potentiometric measurements. The results show that biofouling occurred rapidly within minutes and strongly affected cyclic voltammetry measurements, while potentiometric measurements were minimally affected even after 24 hours. 
Keywords: biofouling, fibrinogen, sensors, potentiometry, cyclic voltammetry, relatively high solubility, electrochemical sensors, human fibrinogen, biocompatibility, adsorption, biosensors