| Authors: | Peng, Q.; Li, K.; Han, Z.; Wang, E.; Xu, Z.; Liu, R.; Tian, Y. |
| Title: | Degradable magnesium-based implant materials with anti-inflammatory activity |
| Type: | Journal Article |
| Publisher: | J Biomed Mater Res A |
| Year: | 2013 |
| Volume: | 101 |
| Issue: | 7 |
| Start Page: | 1898 |
| End Page: | 1906 |
| DOI: | 10.1002/jbm.a.34494 |
| WEB-link: | http://www.ncbi.nlm.nih.gov/pubmed/23203562 |
| Abstract: | The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening. In addition, the alloys exhibited good cytocompatibility. The anti-inflammatory function of degradation products was identified by both interleukin-1alpha and nitric oxide modes. The anti-inflammatory impact was significantly associated with the concentration of silver ion. It was demonstrated that Mg-Zn-Ag system was a potential metallic stent with anti-inflammatory function, which can reduce the long-term dependence of anti-inflammatory drug after coronary stent implantation. |
| File: | (648K) |
