Publication details

Authors: Cui, W.; Beniash, E.; Gawalt, E.; Xu, Z.; Sfeir, C. 
Title: Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition 
Type: Journal Article 
Publisher: Acta Biomaterialia 
Year: 2013 
Issue: 10 
Start Page: 8650 
End Page: 8659 
DOI: 10.1016/j.actbio.2013.06.031 
Abstract: Degradable metals have been suggested as biomaterials with revolutionary potential for bone-related therapies. Of these candidate metals, magnesium alloys appear to be particularly attractive candidates because of their non-toxicity and outstanding mechanical properties. Despite their having been widely studied as orthopedic implants for bone replacement/regeneration, their undesirably rapid corrosion rate under physiological conditions has limited their actual clinical application. This study reports the use of a novel biomimetic peptide coating for Mg alloys to improve the alloy corrosion resistance. A 3DSS biomimetic peptide is designed based on the highly acidic, bioactive bone and dentin extracellular matrix protein, phosphophoryn. Surface characterization techniques (scanning electron microscopy, energy dispersive X-ray spectroscopy and diffuse-reflectance infrared spectroscopy) confirmed the feasibility of coating the biomimetic 3DSS peptide onto Mg alloy AZ31B. The 3DSS peptide was also used as a template for calcium phosphate deposition on the surface of the alloy. The 3DSS biomimetic peptide coating presented a protective role of AZ31B in both hydrogen evolution and electrochemical corrosion tests. (C) 2013 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. 
Keywords: magnesium alloys, corrosion, biomimetic coating, electrochemical corrosion, calcium phosphate, heat-treated magnesium, simulated body-fluid, in-vitro corrosion, dentin phosphophoryn, infrared-spectroscopy, pure magnesium, apatite, hydroxyapatite, conversion, proteins