Publication details

Authors: Smith, Christopher E.; Xu, Zhigang; Waterman, Jenora; Sankar, Jagannathan 
Title: Cytocompatibility assessment of MgZnCa alloys 
Type: Journal Article 
Publisher: Emerging Materials Research 
Year: 2013 
Start Page: 283 
End Page: 290 
DOI: 10.1680/emr.13.00026 
Abstract: The global orthopedic device market is expected to grow by 9% annually, which will equate to US$50 billion by 2015, necessitating innovation in medical devices that improve the quality of life. The first step in the creation of a foundation of knowledge and technology to improve these implant devices is through the creation of new materials with the capabilities of biodegradation and bioabsorption without a toxicity effect that will pass through Food and Drug Administration regulatory procedures. Magnesium and its alloys have gained attention as biomedical implant materials based on biocompatibility and biodegradability. The objective of this study is to investigate the cytocompatibility effects of adding zinc to a magnesiumcalcium system through in-direct cell culture assays utilizing MC3T3-E1 preosteoblast mouse cells. Cell culture assays indicate that there is a level of cytotoxicity that develops from adding zinc to a magnesiumcalcium system, but descriptive evidence suggests that solution heat treatment may reduce these cytotoxic effects. 
Keywords: alloys; characterization; optical microscopy; scanning electron microscopy