Publication details

Authors: Singh, Satish S.; Roy, Abhijit; Lee, Boeun E.; Ohodnicki, John; Loghmanian, Autrine; Banerjee, Ipsita; Kumta, Prashant N. 
Title: A study of strontium doped calcium phosphate coatings on AZ31 
Type: Journal Article 
Publisher: Materials Science and Engineering: C 
Year: 2014 
Volume: 40 
Start Page: 357 
End Page: 365 
DOI: 10.1016/j.msec.2014.03.062 
Abstract: Calcium phosphate (CaP) coatings have been studied to tailor the uncontrolled non-uniform corrosion of Mg based alloys while simultaneously enhancing bioactivity. The use of immersion techniques to deposit CaP coatings is attractive due to the ability of the approach to coat complex structures. In the current study, AZ31 substrates were subjected to various pretreatment conditions prior to depositing Sr2 + doped and undoped CaP coatings. It was hypothesized that the bioactivity and corrosion protection of CaP coatings could be improved by doping with Sr2 +. Heat treatment to elevated temperatures resulted in the diffusion of alloying elements, Mg and Zn, into the pretreated layer. Sr2 + doped and undoped CaP coatings formed on the pretreated substrates consisted of biphasic mixtures of -tricalcium phosphate (-TCP) and hydroxyapatite (HA). Electrochemical corrosion experiments indicated that the extent of Sr2 + doping and pretreatment both influenced the corrosion protection. Cytotoxicity was evaluated with MC3T3-E1 mouse preosteoblasts and human mesenchymal stem cells (hMSCs). For both cell types, proliferation decreased upon increasing the Sr2 + concentration. However, both osteogenic gene and protein expression significantly increased upon increasing Sr2 + concentration. These results suggest that Sr2 + doped coatings are capable of promoting osteogenic differentiation on degradable Mg alloys, while also enhancing corrosion protection, in comparison to undoped CaP coatings. 
Keywords: Calcium phosphate, Strontium, Magnesium alloy, Osteogenic differentiation