Publication details

Authors: Carter, P.; Rahman, S. M.; Bhattarai, N. 
Title: Facile fabrication of aloe vera containing PCL nanofibers for barrier membrane application 
Type: Journal Article 
Publisher: Journal of Biomaterials Science-Polymer Edition 
Year: 2016 
Volume: 27 
Start Page: 692 
End Page: 708 
DOI: 10.1080/09205063.2016.1152857 
Abstract: Guided tissue regeneration (GTR) is a widely used method in dental surgical procedures that utilizes a barrier membrane to exclude migration of epithelium and ensure repopulation of periodontal ligament cells at the sites having insufficient gingiva. Commercial GTR membranes are typically composed of synthetic polymers that have had mild clinical success mostly because of their lack of proper bioactivity and appropriate degradation profile. In this study, a natural polymer, aloe vera was blended with polycaprolactone (PCL) to create nanofibrous GTR membranes by electrospinning. Aloe vera has proven anti-inflammatory properties and enhances the regeneration of periodontium tissues. PCL, a synthetic polymer, is well known to produce miscible polyblends nanofibers with natural polymers. Nanofibrous membranes with varying composition of PCL to aloe vera were fabricated, and several physicochemical and biological properties, such as fiber morphology, wettability, chemical structure, mechanical strength, and cellular compatibility of the membranes were analyzed. PCL/aloe vera membranes with ratios from 100/00 to 70/30 showed good uniformity in fiber morphology and suitable mechanical properties, and retained the integrity of their fibrous structure in aqueous solutions. Experimental results, using cell viability assay and cell attachment observation, showed that the nanofibrous membranes support 3T3 cell viability and could be a potential candidate for GTR therapy. 
Keywords: aloe vera, nanofiber, electropsinning, polycaprolectone, guided tissue regeneration, biomedical applications, polyblend nanofibers, scaffold, proliferation, biomaterials, acemannan, myotubes, collagen, growth, gel