Publication details

Authors: Koo, Y.; Lee, H. B.; Dong, Z.; Kotoka, R.; Sankar, J.; Huang, N.; Yun, Y. 
Title: The Effects of Static and Dynamic Loading on Biodegradable Magnesium Pins In Vitro and In Vivo 
Type: Journal Article 
Publisher: Scientific Reports 
Year: 2017 
Start Page: 14710 
End Page:  
DOI: 10.1038/s41598-017-14836-5 
Abstract: Here we systematically assess the degradation of biodegradable magnesium pins (as-drawn pure Mg, as-cast Mg-Zn-Mn, and extruded Mg-Zn-Mn) in a bioreactor applying cyclical loading and simulated body fluid (SBF) perfusion. Cyclical mechanical loading and interstitial flow accelerated the overall corrosion rate, leading to loss of mechanical strength. When compared to the in vivo degradation (degradation rate, product formation, uniform or localized pitting, and stress distribution) of the same materials in mouse subcutaneous and dog tibia implant models, we demonstrate that the in vitro model facilitates the analysis of the complex degradation behavior of Mg-based alloys in vivo. This study progresses the development of a suitable in vitro model to examine the effects of mechanical stress and interstitial flow on biodegradable implant materials. 
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