| Authors: | Devi, K. Bavya; Lee, Boeun; Roy, Abhijit; Kumta, Prashant N.; Roy, Mangal |
| Title: | Effect of zinc oxide doping on in vitro degradation of magnesium silicate bioceramics |
| Type: | Journal Article |
| Publisher: | Materials Letters |
| Year: | 2017 |
| Volume: | 207 |
| Issue: | |
| Start Page: | 100 |
| End Page: | 103 |
| DOI: | https//.org/10.1016/j.matlet.2017.07.052 |
| Abstract: | In recent years, silicate based bioceramics have drawn much attention because of its biocompatibility and high bio-degradability. In the present study, 0.25 and 0.5wt% zinc doped magnesium silicate (MgS) ceramics were prepared by solid state synthesis and sintering at 1200°C for 2h. In vitro biodegradation study in simulated body fluid (SBF) showed increased weight loss while micro-computed tomography (µ-CT) analysis showed increased porosity for the zinc oxide doped samples. The µ-CT results also indicated interconnected porous structure having pore sizes of nearly 510580µm. In vitro cytocompatibility study showed attachment and proliferation of MC3T3-E1 cells on pure and doped MgS samples. Thus, the present study shows that zinc addition enhances the biodegradability of magnesium silicate and supports cell proliferation, making it a suitable material for temporary bone replacement. |
| Keywords: | Magnesium silicate, Micro-computed tomography, Zinc doping, Cell culture |
