Publication details

Authors: Devi, K. Bavya; Lee, Boeun; Roy, Abhijit; Kumta, Prashant N.; Roy, Mangal 
Title: Effect of zinc oxide doping on in vitro degradation of magnesium silicate bioceramics 
Type: Journal Article 
Publisher: Materials Letters 
Year: 2017 
Volume: 207 
Start Page: 100 
End Page: 103 
DOI: https//.org/10.1016/j.matlet.2017.07.052 
Abstract: In recent years, silicate based bioceramics have drawn much attention because of its biocompatibility and high bio-degradability. In the present study, 0.25 and 0.5wt% zinc doped magnesium silicate (MgS) ceramics were prepared by solid state synthesis and sintering at 1200C for 2h. In vitro biodegradation study in simulated body fluid (SBF) showed increased weight loss while micro-computed tomography (-CT) analysis showed increased porosity for the zinc oxide doped samples. The -CT results also indicated interconnected porous structure having pore sizes of nearly 510580m. In vitro cytocompatibility study showed attachment and proliferation of MC3T3-E1 cells on pure and doped MgS samples. Thus, the present study shows that zinc addition enhances the biodegradability of magnesium silicate and supports cell proliferation, making it a suitable material for temporary bone replacement. 
Keywords: Magnesium silicate, Micro-computed tomography, Zinc doping, Cell culture