| Authors: | Desai, Salil; Perkins, Jessica; Harrison, Benjamin S.; Sankar, Jag. |
| Title: | Understanding release kinetics of biopolymer drug delivery microcapsules for biomedical applications. |
| Type: | Journal Article |
| Publisher: | Mater. Sci. Eng., B |
| Year: | 2010 |
| Volume: | 168 |
| Issue: | 1-3 |
| Start Page: | 127 |
| End Page: | 131 |
| Abstract: | Drug delivery and dosage concns. are considered as major focal points in conventional as well as battlefield emergency medicine. The concept of localizing drug delivery via microcapsules is an evolving field to confine the adverse side effects of high concn. drug doses. This paper focuses on understanding release kinetics through biopolymer microcapsules for time-dependent drug release. Calcium alginate microcapsules were manufd. using a direct-write inkjet technique. Rhodamine 6G was used as the release agent to observe the release kinetics from calcium alginate beads in distd. water. A design of expts. was constructed to compare the effect of the microcapsule diam. and different concns. of calcium chloride (M) and sodium alginate (%, w/v) solns. on the release kinetics profiles of the microcapsules. This research gives insight to identify favorable sizes of microcapsules and concns. of sodium alginate and calcium chloride solns. for controlled release behavior of drug delivery microcapsules. [on SciFinder (R)] |
| Keywords: | Controlled-release drug delivery systems; Dissolution; Particle size; Particle size distribution; Pharmaceutical microcapsules (release kinetics of biopolymer drug delivery microcapsules for biomedical applications); Drug delivery systems (targeted; release kinetics of biopolymer drug delivery microcapsules for biomedical applications) |
