| Authors: | Ye, Sang-Ho; Johnson, Carl A., Jr.; Woolley, Joshua R.; Murata, Hironobu; Gamble, Lara J.; Ishihara, Kazuhiko; Wagner, William R.. |
| Title: | Simple surface modification of a titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity. |
| Type: | Journal Article |
| Publisher: | Colloids Surf., B |
| Year: | 2010 |
| Volume: | 79 |
| Issue: | 2 |
| Start Page: | 357 |
| End Page: | 364 |
| Abstract: | Thrombosis and thromboembolism remain problematic for a large no. of blood contacting medical devices and limit broader application of some technologies due to this surface bioincompatibility. In this study the authors focused on the covalent attachment of zwitterionic phosphorylcholine (PC) or sulfobetaine (SB) moieties onto a TiAl6V4 surface with a single step modification method to obtain a stable blood compatible interface. Silanated PC or SB modifiers (PCSi or SBSi) which contain an alkoxy silane group and either PC or SB groups were prepd. resp. from trimethoxysilane and 2-methacryloyloxyethyl phosphorylcholine (MPC) or N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine (SMDAB) monomers by a hydrosilylation reaction. A cleaned and oxidized TiAl6V4 surface was then modified with the PCSi or SBSi modifiers by a simple surface silanization reaction. The surface was assessed with XPS, attenuated total reflection-Fourier transform IR spectroscopy (ATR-FTIR) and contact angle goniometry. Platelet deposition and bulk phase activation were evaluated following contact with anticoagulated ovine blood. XPS results verified successful modification of the PCSi or SBSi modifiers onto TiAl6V4 based on increases in surface phosphorous or sulfur resp. Surface contact angles in water decreased with the addn. of hydrophilic PC or SB moieties. Both the PCSi and SBSi modified TiAl6V4 surfaces showed decreased platelet deposition and bulk phase platelet activation compared to unmodified TiAl6V4 and control surfaces. This single step modification with PCSi or SBSi modifiers offers promise for improving the surface hemocompatibility of TiAl6V4 and is attractive for its ease of application to geometrically complex metallic blood contacting devices. [on SciFinder (R)] |
| Keywords: | Anticoagulants; Biocompatibility; Hydrosilylation; Silylation; Surface structure; Surface treatment; Wettability (surface modification of titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity); Sulfobetaines Role: PEP (Physical, engineering or chemical process), PRP (Properties), TEM (Technical or engineered material use), THU (Therapeutic use), BIOL (Biological study), PROC (Process), USES (Uses) (surface modification of titanium alloy with silanated zwitterionic phosphorylcholine or sulfobetaine modifiers to reduce thrombogenicity) |
