| Authors: | Hong, Yi; Guan, Jianjun; Fujimoto, Kazuro L.; Hashizume, Ryotaro; Pelinescu, Anca L.; Wagner, William R.. |
| Title: | Tailoring the degradation kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds. |
| Type: | Journal Article |
| Publisher: | Biomaterials |
| Year: | 2010 |
| Volume: | 31 |
| Issue: | 15 |
| Start Page: | 4249 |
| End Page: | 4258 |
| Abstract: | Biodegradable elastomeric scaffolds are of increasing interest for applications in soft tissue repair and regeneration, particularly in mech. active settings. The rate at which such a scaffold should degrade for optimal outcomes, however, is not generally known and the ability to select from similar scaffolds that vary in degrdn. behavior to allow such optimization is limited. Our objective was to synthesize a family of biodegradable polyurethane elastomers where partial substitution of polyester segments with polycarbonate segments in the polymer backbone would lead to slower degrdn. behavior. Specifically, we synthesized poly(ester carbonate)urethane ureas (PECUUs) using a blended soft segment of poly(caprolactone) (PCL) and poly(1,6-hexamethylene carbonate) (PHC), a 1,4-diisocyanatobutane hard segment and chain extension with putrescine. Soft segment PCL/PHC molar ratios of 100/0, 75/25, 50/50, 25/75, and 0/100 were investigated. Polymer tensile strengths varied from 14 to 34 MPa with breaking strains of 660-875%, initial moduli of 8-24 MPa and 100% recovery after 10% strain. Increased PHC content was assocd. with softer, more distensible films. Scaffolds produced by salt leaching supported smooth muscle cell adhesion and growth in vitro. PECUU in aq. buffer in vitro and s.c. implants in rats of PECUU scaffolds showed degrdn. slower than comparable poly(ester urethane)urea and faster than poly(carbonate urethane)urea. These slower degrading thermoplastic polyurethanes provide opportunities to investigate the role of relative degrdn. rates for mech. supportive scaffolds in a variety of soft tissue repair and reconstructive procedures. [on SciFinder (R)] |
| Keywords: | Medical goods (biodegradable; tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds); Biodegradable materials (medical goods; tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds); Adhesion; Contact angle; Decomposition kinetics; Smooth muscle; Tensile strength; Viscosity (tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds); Thermoplastic rubber Role: PRP (Properties), SPN (Synthetic preparation), TEM (Technical or engineered material use), THU (Therapeutic use), BIOL (Biological study), PREP (Preparation), USES (Uses) (tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds); Urethane rubber Role: PRP (Properties), THU (Therapeutic use), BIOL (Biological study), USES (Uses) (tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds); Tissue engineering (tissue engineering scaffolding; tailoring the degrdn. kinetics of poly(ester carbonate urethane)urea thermoplastic elastomers for tissue engineering scaffolds) |
