| Authors: | Cui, W.; Beniash, E.; Gawalt, E.; Xu, Z.; Sfeir, C. |
| Title: | Biomimetic coating of magnesium alloy for enhanced corrosion resistance and calcium phosphate deposition |
| Type: | Journal Article |
| Publisher: | Acta Biomaterialia |
| Year: | 2013 |
| Volume: | 9 |
| Issue: | 10 |
| Start Page: | 8650 |
| End Page: | 8659 |
| DOI: | 10.1016/j.actbio.2013.06.031 |
| WEB-link: | http://ac.els-cdn.com/S1742706113003243/1-s2.0-S1742706113003243-main.pdf?_tid=461af848-be01-11e3-9cad-00000aacb360&acdnat=1396840023_2b5f33387bf0eaed0dac3642ded3c1d5 |
| Abstract: | Degradable metals have been suggested as biomaterials with revolutionary potential for bone-related therapies. Of these candidate metals, magnesium alloys appear to be particularly attractive candidates because of their non-toxicity and outstanding mechanical properties. Despite their having been widely studied as orthopedic implants for bone replacement/regeneration, their undesirably rapid corrosion rate under physiological conditions has limited their actual clinical application. This study reports the use of a novel biomimetic peptide coating for Mg alloys to improve the alloy corrosion resistance. A 3DSS biomimetic peptide is designed based on the highly acidic, bioactive bone and dentin extracellular matrix protein, phosphophoryn. Surface characterization techniques (scanning electron microscopy, energy dispersive X-ray spectroscopy and diffuse-reflectance infrared spectroscopy) confirmed the feasibility of coating the biomimetic 3DSS peptide onto Mg alloy AZ31B. The 3DSS peptide was also used as a template for calcium phosphate deposition on the surface of the alloy. The 3DSS biomimetic peptide coating presented a protective role of AZ31B in both hydrogen evolution and electrochemical corrosion tests. (C) 2013 Published by Elsevier Ltd. on behalf of Acta Materialia Inc. |
| Keywords: | magnesium alloys, corrosion, biomimetic coating, electrochemical corrosion, calcium phosphate, heat-treated magnesium, simulated body-fluid, in-vitro corrosion, dentin phosphophoryn, infrared-spectroscopy, pure magnesium, apatite, hydroxyapatite, conversion, proteins |
