Univ.-Prof. Dr.med. FRANK WITTE

Prof. for Bioactive Implants
Phone: +49 30 450 559083
Email: frank.witte@charite.de
URL:  http://jwi.charite.de, http://bcrt.charite.de, http://www.biodegradablemetals.org

EDUCATION
Hannover Medical School, Germany, and  Human Medicine MD/Ph.D., 2001
Hannover Medical School, Germany, and Human Medicine MD, 2000
Univ. of Saarbrücken, Germany , and Human Medicine B. Sc., 1994

APPOINTMENTS
2013-present Professor for Bioactive Implants, Charité - Universitätsmedizin Berlin
2006-2013 Dpt. Manager Implant Immunology, Hannover Medical School, CrossBIT  
2009-2013 Associate Prof. Exp. Orthopedics, Hannover Medical School   
2008-2012 Adjunct Prof. Bioengineering, North Carolina A&T State University, USA 
2003-2013 Director for Biomaterial Research, Hannover Medical School, Dpt. of Orthopedics 
2000-2003 Resident/Sr. Res. Assoc., Hannover Medical School, Dpt. of Orthopedics                           

RESEARCH  INTERESTS
Bone Biology, Degradable Biomaterials, Biodegradable Magnesium Alloys, Microtomography, Cell Culture, Animal Models
Immune Response to Biomaterials (in-vitro and in-vivo)
Synchrotron-radiation based microtomography (HASYLAB at DESY)
In-Vivo Fluorescence Imaging for Biomaterial-Host-Interaction

TEACHING  INTERESTS
Biomedicine for Bioengineers
Bone Biology
Biomaterials
Biodegradable Metals
Immune Response to Implants
Basics in Histomorphology and Histomorphometry

Lecturer at Leibniz Uni. of Hannover and MHH “Biomedical Engineering” (since 2003), MS. level: Guest lecturer at Technical University of Delft, Holland, “Biomedical Engineering” (since 2008) for B.Sc. and M.S. students: Guest lecturer at Sami Shamoon College of Engineering, Beer Sheva, Israel (since 2004) for B.Sc. and M.S. students,

PUBLICATIONS

  1. Directly Related to Project
  2. Zeng R, Dietzel W, Witte F, Hort N, Blawert C. “Progress and challenge for magnesium alloys as biomaterials” Advanced Engineering Materials 10 (8), pp. B3-B14+702
  3. Witte F, Abeln I, Switzer E, Kaese V, Meyer-Lindenberg A, Windhagen H. “Evaluation of the skin sensitizing potential of biodegradable magnesium alloys.” J Biomed Mater Res A 2008, 15;86(4):1041-7
  4. Witte F, Fischer J, Beckmann F, Störmer M, Hort N. “3D microstructural analysis of Mg-Al-Zn alloys by synchrotron-radiation based microtomography.”  Script Mat 2008, 58:453–456
  5. Witte F, Ulrich H, Palm C, Willbold E. “Biodegradable magnesium scaffolds: Part II: Peri-implant bone remodeling.” J Biomed Mater Res A 2007, 81A:757-765
  6. Witte F, Ulrich H, Rudert M, Willbold E. “Biodegradable magnesium scaffolds: Part I: Appropriate inflammatory response.” J Biomed Mater Res A 2007, 81A:748-756
  7. Witte F, Feyerabend F, Maier P, Fischer J, Störmer M, Blawert C, Dietzel W, Hort N. “Biodegradable magnesium-hydroxyapatite metal matrix composites.” Biomaterials 2007, 28:2163-2174
  8. Witte F, Fischer J, Nellesen J, Crostack HA, Kaese V, Pisch A, Beckmann F, Windhagen H. “In vitro and in vivo corrosion measurements of magnesium alloys.” Biomaterials 2006, 27:1013-18
  9. Witte F, Reifenrath J, Müller PP, Crostack HA, Nellesen J, Bach FW, Bormann D, Rudert M. “Cartilage repair on magnesium scaffolds used as a subchondral bone replacement.” Materialwiss Werkst 2006, 37:504-508
  10. Feyerabend F, Witte F, Kammal M, Willumeit R. “Unphysiologically high magnesium concentrations support chondrocyte proliferation and redifferentiation.” Tissue Eng 2006, 12:3545-3556
  11. Witte F, Kaese V, Haferkamp H, Switzer E, Meyer-Lindenberg A, Wirth CJ, Windhagen H. “In vivo corrosion of four magnesium alloys and the associated bone response.” Biomaterials 2005, 26:3557-3563

SYNERGISTIC  ACTIVITIES

  • Memberships in International Societies: European Society for Biomaterials; International Chinese Hard Tissue Society; International Bone Research Association.
  • Editorial Board: Acta Biomaterialia, J Biomed Mater Res Part A, Materials Science and Engineering Part B
  • Patents: more than 18 patents in the area of biomedical magnesium alloys

COLLABORATORS  AND  OTHER  AFFILIATIONS (previous 48 months)

Collaborators and Co-Editors (projects or publications)

  • Dr. Vesslin N.Shannov, Dept. of Chemical and Materials Eng., Univ. of Cincinnati, USA
  • Dr. Mark J. Schulz, Dept. of Mechanical Eng. Univ. of Cincinnati, USA
  • Dr. William Wagner, McGowan Center for Regenerative Medicine, Univ. of Pittsburgh, USA
  • Dr. Harvey Borovetz, Department of Bioengineering, University of Pittsburgh, USA
  • Dr. Sergey Yarmolenko, NCA&T State University, USA
  • Dr. Jag Sankar, NCA&T State University, USA
  • Dr. Dan Shechtman, Technion, Haifa, Israel
  • Dr. Carla Vogt, Dept. Analytical Chemistry, Leipzig Univ. of Hannover, Germany
  • Dr. Frank Feyerabend, GKSS, Germany
  • Dr. Norbert Hort, GKSS, Germany
  • Dr. Felix Beckmann, GKSS (at HASYLAB), Germany

Postdoctoral Advisor

  • Dr. Elmar Willbold, Post Doc, Dept. of Orthopedics. Hannover Medical School
  • Dr. Tilman Calliess, Resident/Post Doc, Dept. of Orthopedics, Hannover Medical School
  • Dr. Ivonne Bartsch, Post Doc, CrossBIT, Hannover Medical School
  • Dr. Helga Hornberg, Post Doc, Hannover Medical School
  • Dr. Tanja Schmidt, Post Doc, Charite - Universitätsmedizin Berlin

Thesis Advisor

  • Katharina Bobe, PhD student
  • Fabian Goede, PhD student
  • Kerstin Weinert, PhD student
  • Oliver Palm, PhD student
  • Christiane Palm, PhD student
  • Inken Abeln, PhD student
  • Jutta Seufert, PhD student
  • Carla Janning, PhD student
  • Janin Reifenrath, PhD student
  • Elinor Switzer, PhD student
  • Jan Seifert, MS student