Aaron Barchowsky, Ph.D.
 
Associate Professor of Environmental and Occupational Health
University of Pittsburgh Graduate School of Public Health
Pittsburgh, PA 15219
412 624-8864
Email: aab20@pitt.edu
 
Professional Preparation
·         B.S. Zoology, North Carolina State University, Raleigh, NC, 1978
·         Ph.D. Pharmacology, Duke University, Durham, NC, 1985
·         Post-Doc Toxicology, Duke University, Durham NC,1985-1988
     
Appointments:
·         Associate Professor ( with tenure)– Environmental and Occupational Health, University of Pittsburgh, 2003 -- present
·         Associate Professor (secondary) – Pharmacology, University of Pittsburgh School of Medicine, 2005 -- present
·         Associate Professor – Pharmacology and Toxicology, Dartmouth Medical School, 1998-2003.          
·         Assistant Professor - Pharmacology and Toxicology, Dartmouth Medical School, 1991-1998
·         Research Assistant Professor - Division of Clinical Pharmacology, Thomas Jefferson University 1988 to 1991.
Selected Publications (total peer reviewed publications 73):
·         Shumilla, JA, RJ Broderick, Y Wang, and A Barchowsky. Chromium(VI) inhibits the transciptional activity of Nuclear Factor-kB by decreasing the interaction of p65 with cAMP-responsive element-binding protein-binding protein. J Biol Chem. 274:36207-36212, 1999.
·         Barchowsky, A, NA Soucy, TL Noreault, KA O’Hara, J Hwa, and AS Andrew. A Novel pathway for nickel-induced interleukin-8 expression. J. Biol. Chem. 277:24225-24231, 2002.
·         Soucy, NS, LR Klei, DD Mayka, and A Barchowsky. Signaling Pathways for Arsenic-Stimulated Vascular Endothelial Growth Factor-A Expression in Primary Vascular Smooth Muscle Cells. Chem Res Toxicol. 17:555-563, 2004.
·         O’Hara, KO, AA Nemec, J Alam, LR Klei, BT Mossman, and A Barchowsky. Chromium(VI) inhibits heme oxygenase-1 expression in vivo and in arsenic-exposed human airway epithelial cells. J. Cell. Physiol. 209:113–121, 2006.
·         Straub, AC, DB Stolz, MA Ross, NV Soucy, LR Klei and A Barchowsky. Arsenic stimulates sinusoidal endothelial cell capillarization and vessel remodeling in mouse liver. Hepatology 45:205-212, 2007.
·         O’Hara, KA, R J Vaghjiani, AA Nemec, LR Klei and A Barchowsky. Chromium(VI)-stimulated STAT3 tyrosine phosphorylation and nuclear translocation in human airway epithelial cells requires Lck. Biochem J. 402:261-269, 2007.
·         Straub AC, KA Clark, MA Ross, AG Chandra, S Li, X Gao, PJ Pagano, DB Stolz, and A Barchowsky. Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide. J. Clin. Invest. 118:3980-9, 2008.
·         Nemec AA, GD Leikauf, BR Pitt, KJ Wasserloos, and A Barchowsky. Nickel mobilizes intracellular zinc to induce metallothionein in human airway epithelial cells. Am J Resp Cell Mol Biol In Press Dec 12, 2008.
·         Straub AC, LR Klei, DB Stolz, A Barchowsky. Arsenic requires sphingosine-1-phosphate type 1 receptors to induce angiogenic genes and endothelial cell remodeling. Am J Pathol 174, May 2009.
Professional Affiliations:
Society of Toxicology
American Physiological Society
North American Vascular Biology Organization.
Synergistic Activities
·         Director, Environmental Health Sciences Ph.D. Training Program.
·         Director, Summer Undergraduate Internship Program in Environmental Health Sciences.
·         Director, Graduate School of Public Health core MPH curriculum course: Environmental Health and Disease.
·         Chair, Society of Toxicology Education Committee
·         Vice President, Society of Toxicology Metals Specialty Section.
·         Vice President, Allegheny & Erie Regional Chapter of the Society of Toxicology
·         Member of numerous National Institutes of Health study sections and review panels.
·         Member, US Environmental Protection Agency, Scientific Advisory Board, Arsenic Special Emphasis Panel (2005-present)
·         National Academies of Science, Committee on the framework for evaluating the safety of dietary supplements; Chromium Picolinate I Working Group (2002)
·         American Heart Association, Northeast Affiliate, Research Committee (1996-2003)
·         Advisory Board, CDC-funded University of Pittsburgh Academic Consortium for Excellence in Environmental Public Health Tracking (2006-present). 
·         Associate editor, Toxicological Sciences
·         Associate editor, Cardiovascular Toxicology
·         Associate editor, Journal of Cellular Physiology.
 
Collaborators
 University of Pittsburgh: BR Pitt, DB Stolz, C Sfeir, P Kumta, GD Leikauf, PJ Pagano. Duquesne University: P Basu, JF Stolz.
Graduate and Post Doctoral Advisors
Ph.D. Thesis Director: Dr. A. Richard Whorton, Duke Univeristy
Postdoctoral Director: Dr. A. Richard Whorton, Duke Univeristy
Thesis Advisor and Postgraduate-Scholar Sponsor
 
High School Student: Harina Vin (Summer research fellow 2006; Allegheny & Erie Regional Society of Toxicology Chapter research Award)
Undergraduate thesis advisor at Dartmouth College:EW. Springer, LC Elmore, BM Lannon, AL Ulfers, RJ Broderick, BC Richardson, C Biedron. 
Undergraduate advisor University of Pittsburgh: R Vaghjiani, L Zubritsky.
Ph.D. Graduate Students at Dartmouth Medical School: MD Treadwell, JA Shumilla, RR Roussel, AS Andrew, NV Soucy, K A O’Hara.
Ph.D. Graduate Students University of Pittsburgh:AC Straub, A A Nemec.
Postdoctoral Scholar: KR Smith 
Sabbatical Scholar: P Basu